Increased MCA310 tumor growth in IL-17–deficient mice. 3-Methylcholanthrene (MCA)–induced fibrosarcoma MCA310 tumors were maintained in vivo by serial subcutaneous transplantation in C57BL/6 mice. Tumor-cell suspensions were prepared from solid tumors by enzymatic digestion. Wild-type (WT) and IL-17–deficient (IL-17^−/−) mice were subcutaneously inoculated with 1.2 × 10⁶ tumor cells in the lower flank. Twelve days after tumor inoculation, tumors were harvested and weighed. Results were expressed as mean ± SEM; 2 independent experiments were performed with 5 animals per experiment per group. *P < .05.