Evolution of Sμ mutations over time in serial lymph node biopsies. Thirty-six pairs of serial biopsies were studied. One pair was excluded from the analysis as the second biopsy, obtained only 1 month after diagnosis, had not been motivated by a suspicion of transformation but rather to confirm histology (no. 927). (A) Comparison of the median number of mutations in serial lymph nodes (36 pairs). (B) Correlation between the evolution of the mutations and the interval between relapses. Pairs that did (12 pairs) or did not (24 pairs) show mutations losses are compared. Boxes show the range between the 25th and 75th percentiles, with a horizontal line at the median value. Whiskers extend to the 10th and 90th percentile of values.