Two patterns of changes in monoclonal immunoglobulin level during progression to myeloma. (A) The change in monoclonal immunoglobulin level before the diagnosis of myeloma in patients with a diagnostic monoclonal immunoglobulin greater than 3 g/dL. (B) The change in monoclonal immunoglobulin level before the diagnosis of myeloma in patients with a diagnostic monoclonal immunoglobulin less than 3 g/dL.