Physiologic functions of miR-34a in primary B-CLL cells and the prolymphocytic MEC1 cell line. (A) In vitro miR-34a overexpression induces apoptosis in B-CLL cells in a p53-dependent manner and (B) in cell line MEC1. Antisense suppression of miR-34a has no effect. NTC indicates nontargeting control oligonucleotide. Box length equals interquartile range (*P < .05; **P < .01).