Lyn regulates the association between PKC-δ and SHIP-1. Washed, indomethacin-treated WT littermates (A) and Lyn^−/− mice (B) were stimulated with 500 μM AYPGKF or 100 ng/mL CVX, immunoprecipitated with total PKC-δ, and probed for pSHIP-1 and total PKC-δ, respectively. Rabbit IgG was used as a negative control for the coimmunoprecipitation experiment.