Schematic domain architecture of Kindlins. Overlap of the defined subdomains with the conserved and nonconserved regions. F0, F1, F2, and F3 indicate subdomains of the FERM domain; and PH, pleckstrin homology domain. Variable region (V) intersects the F1 subdomain, splitting it into 2 parts. PH domain intersects the F2 subdomain. Numbers of Kindlin-3 amino acid residues are shown on the top.