In vitro analysis of Ad5 hexon point mutants. (A) Cell binding at 4°C to SKOV3 cells in the presence or absence of physiologic concentrations of FX, (*P < .01 vs no FX conditions). (B) Fold change in FX-assisted virus association with cell versus absence of FX. (C) SKOV3 cell transduction at 48-hour postinfection after a 3-hour exposure to each virus in the presence or absence of FX in serum-free conditions (P < .001 vs no FX conditions).