Pharmacokinetics of AC220. (A) Time course of AC220 plasma levels in NU/NU mice after a single oral administration at 10 mg/kg. The average values from 3 independent time courses are shown in black and individual values, in red. (B) Dose dependence of AC220 peak plasma levels (C_max) and exposure (AUC_{0-24 hours}). The insets show a zoomed view of the data at dosages of 10 mg/kg and below. Average values from 3 independent time courses are shown in black and individual values, in red.