ALMC λLC variable region amino acid sequence. (A) The amino acid sequence of the ALMC-1, ALMC-2, and primary patient PCs before and after PBSCT (designated ALMC-1/2) λLC variable region is shown relative to the germ line IGLV6-57 gene. (B) Model of the ALMC λLC variable region showing the location of each mutation based on the crystal structure of the lambda 6 IGLV protein Wil. The putative structural locations of each amino acid mutation are indicated, β sheets are shown in light gray, and loops are shown in black.