DNA copy-number changes and mRNA expression of the CASP8AP2 gene in T-ALL. Frequencies of DNA copy-number imbalances on chromosome 6 in leukemias with favorable (A) and unfavorable (B) MRD kinetics. Clones are plotted in chromosome order. Representative array-CGH profile of chromosome 6 from a T-ALL with deletion of CASP8AP2 (C). Aberrations are indicated by arrows. All data points are shown as log₂-ratios comparing leukemia DNA with a pool of normal blood DNA from 10 donors. Expression of CASP8AP2 transcripts as assessed by quantitative RT-PCR in primary T-ALL with balanced (n = 48; left box plot) and deleted chromosome band 6q15-16.1 (n = 6; right box plot). Stars indicate measurement outliers beyond the 5th and 95th percentile (D).