Aberrations of single chromosomes affecting genes in leukemogenic pathways. Representative array-CGH profiles of single chromosomes from T-ALL with homozygous deletions of CDKN2A/CDKN2B (A), heterozygous deletion of CDKN1B (B), homozygous deletions of PTEN (C) or TFDP3 (D), amplification of MYB (E), as well as an amplification of ABL1/NUP214 and a heterozygous deletion of CDKN2A/CDKN2B (F). Aberrations are indicated by arrows. All data points are shown as log₂-ratios comparing T-ALL DNA with a pool of normal blood DNA from 10 donors. Clones are plotted in chromosome order.