Restoration of retinal vascularization in CYP1B1^−/− mice treated with NAC. Frozen eye sections from P17 CYP1B1^+/+ (A,C) and CYP1B1^−/− (B,D) mice exposed to OIR receiving solvent control (A,B) or NAC (10 mg/kg in 0.1 mL IP) from P12 to P17, were stained with anti-endoglin antibody (×400). Please note significant vascularization in CYP1B1^−/− retina treated with NAC compared with solvent control. The degree of neovascularization was quantified as described in Figure 1 and shown in panel E (n = 15, *P < .05).