Colocalization of FVIII and VWF in macrophages. Merged image of a spleen tissue section of a VWF-deficient mouse infused with VWF/FVIII complex (10 and 0.25 μg/mouse, respectively) stained with anti–human VWF antibodies (red) and monoclonal anti–human FVIII antibody LE2E9 (green).