Comparison of the effect of poly I:C and LPS on fibrin(ogen) deposition in WT and TLR3^−/−mice in vivo. Mice were treated with poly I:C, LPS, or PBS, and the liver (A) and kidneys (B) were removed for fibrin(ogen) analysis. Sections were stained with an anti–fibrin(ogen) rabbit polyclonal antibody, and the visualization was done with rhodamine-coupled secondary antibody. From each treatment group, 3 mice were analyzed. Slides were counterstained with DAPI to show the nuclei.