Comparison of the effect of poly I:C and LPS on plasma D-dimer, TAT, IL-6, TNF-α, and IFN-β in WT and TLR3^−/− mice in vivo. WT or TLR3^−/− mice were given 250 μg poly I:C or 50 μg LPS or the equivalent volume of PBS (IV), and after 12 hours, plasma was collected, and the levels of D-dimer (A), TAT (B), IL-6 (C), TNF-α (D), and IFN-β (E) were determined by enzyme-linked immunosorbent assay (ELISA). There were 8 to 20 mice in each group, and the results are presented as mean plus SEM. Statistical significance was determined using 2-way ANOVA followed by Bonferroni posttest. *P < .05.