DC cocultured with IL-2– or IL-12–conditioned NK cells induce an environment of inflammatory type. NK cells that had been exposed to IL-4, IL-12, IL-2, IL-18, or a combination of these cytokines during 40 hours were washed and further cultured together with iDCs for 24 hours. Cytokine levels were measured in supernatants of these cocultures. Cytokine secretions were normalized to 100% for control iDCs. Data represent means plus or minus SD of 3 independent experiments. ND indicates not determined. *P < .05; **P < .01; ***P < .001.