Figure 7
Figure 7. Impaired BCR-induced expression of c-Myc and Bcl-XL in TAK1-deficient B cells. Splenic mature B cells (AA4.1−) were isolated from CD19CreTak1+/+ and CD19CreTak1fl/fl mice. Cells were stimulated with anti-IgM for the indicated times. Cell lysates were subjected to direct Western blot analysis with anti-c-Myc (A), anti-Bcl-XL (B), or anti-actin antibodies. Data are representative of 2 individual experiments.

Impaired BCR-induced expression of c-Myc and Bcl-XL in TAK1-deficient B cells. Splenic mature B cells (AA4.1−) were isolated from CD19CreTak1+/+ and CD19CreTak1fl/fl mice. Cells were stimulated with anti-IgM for the indicated times. Cell lysates were subjected to direct Western blot analysis with anti-c-Myc (A), anti-Bcl-XL (B), or anti-actin antibodies. Data are representative of 2 individual experiments.

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