Heat map of selected gene alterations detected in the comparison of L-HES patients (P1-P3) vs controls. A total of 198 of the commonly altered genes detected in all 3 patients were selected from supplemental Table 2 based on their functional relevance (one probe set/gene is shown and represents the greatest absolute fold change in patients relative to controls). The genes are classified in functional groups and listed in numerical order based on fold change with the same order and group numbers maintained in the heat map. Each column in the heat map represents the expression from an individual gene chip and includes the 4 healthy controls (C1-C4), triplicates of P1-yr 0 (a-c), and duplicates of P2 and P3 (a-b). The clustering and the heat map were generated using R 2.5.1. The dendrogram was derived from a group of selected genes using the hierarchical clustering method and shows the relatedness of gene expression patterns in the L-HES patients relative to the controls.