Venn diagram of altered gene probe sets in the L-HES patients (P1-P3) vs controls. Significant changes in the expression of gene probe sets were based on a P < .05 after Z transformation of the mean S-score values obtained from all possible 2-chip comparisons between triplicates of P1-yr 0 or duplicates of P2-yr 0 and P3-yr 0 and individual arrays from 4 controls (supplemental data). The number of altered probe sets is shown, and the individual genes are listed in supplemental Table 2. *Among the 1469 commonly changed probe sets detected in the comparison of P1 to P3 vs controls, only 1397 probe sets passed a further filter that was applied to probe sets with a P > .01 and/or with fold change < 2 for at least 1 patient.