Analysis of carotid arterial thrombosis in mice. Representative flow tracings recorded in response to FeCl₃ injuryto carotid arteries of (A) Flox/flox and (B) Flox/flox/Cre mice. Time of stable occlusion is shown by an arrow. (C) Graphic representation of flow (mL/min) as a function of time for Flox/flox and Flox/floxCre mice. P < .05 for all times from 4 minutes to 15 minutes. (D) Time to stable occlusion (stable occlusion is defined as patency ≤ 25% for ≥ 3 minutes) is plotted as a Kaplan-Meier Curve for the same mice. By log rank analysis, P = .001. There were no significant differences between males and females in their flow rates or propensity to occlude in either group.