Modulation of drug-resistance by 2-DG. Graphic representation of in vitro responsiveness to cytotoxic drugs in 2 prednisolone-resistant ALL cell lines after 2-DG treatment, as assessed by the MTT assay. Concentrations used were 1 mM (Molt4) or 2 mM 2-DG (Jurkat), 550 μg/mL prednisolone, 100 μg/mL dexamethasone, 0.5 ng/mL vincristine, and 0.0098 U/mL L-asparaginase. Cell survival in cells treated only with 2-DG was set at 100% to visualize the effect of synergy. Representative experiments are shown; data are presented as means plus or minus SD (n = 3).