Alloantigen expression on pDCs alone is sufficient to stimulate alloreactive CD8+ T cells. CD8+ T cells from AKR (CD90.2−) mice were transferred to irradiated β2m−/− C3H (CD90.2+) mice preinjected with WT B cells, pDCs, or cDCs. Expansion of CD90.2− donor CD8+ T cells in mLNs (A) and IFN-γ expression on donor CD8+ T cells in spleens (B) 6 days after transfer are shown as means plus or minus SEM. Data are representative of 2 similar experiments. *P < .05.