Independent JAK2 V617F mutations occur in ET but not in PV. In ET, the presence of JAK2 does not suppress JAK2 WT hematopoiesis. The JAK2 WT progenitors are susceptible to independent JAK2 V617F mutations.

Independent JAK2 V617F mutations occur in ET but not in PV. In ET, the presence of JAK2 does not suppress JAK2 WT hematopoiesis. The JAK2 WT progenitors are susceptible to independent JAK2 V617F mutations.

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