(A) Steady state of the Myb/miR-15a regulatory loop, resulting in feedback inhibition of MYB, preventing excessive cell proliferation and survival. (B) Deletion of 13q14 (comprising the miR-15a gene locus) is frequent in B-CLL. This could result in an increased abundance of Myb, inducing increased cell proliferation and survival.

(A) Steady state of the Myb/miR-15a regulatory loop, resulting in feedback inhibition of MYB, preventing excessive cell proliferation and survival. (B) Deletion of 13q14 (comprising the miR-15a gene locus) is frequent in B-CLL. This could result in an increased abundance of Myb, inducing increased cell proliferation and survival.

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