Representative photographs of the malignant melanoma-bearing mice and H&E staining of normal tissue of the tTF-NGR–treated mice. (A) Mice are shown 20 minutes after injection of tTF-NGR (left) and saline (right). The tumor treated with tTF-NGR was bruised and blackened, indicating blood pooling due to vascular disruption. (B) The resected tumor treated with tTF-NGR exhibited areas of hemorrhage in contrast to the vital appearance of the tumor treated with saline (C). Heart (D), kidney (E), liver (F), and lung (G) of the tTF-NGR–treated tumor-bearing mice showed no visible thrombosis. Original magnification, ×200.