Figure 2
![Figure 2. Erythropoietin but not hypoxia inhibits hepcidin induction through the inflammatory pathway. (A) Hepcidin mRNA levels in the liver of mice treated with saline (control [CTL]), EPO, LPS, and mice with combined treatments (EPO + LPS). (B) Hepcidin mRNA levels in the liver of mice treated with saline (CTL), mice subjected to 10% oxygen (hypoxia [Hpx]), LPS, and mice with combined treatments (Hpx + LPS). Hepatic hepcidin expression was quantified by real-time RT-PCR and normalized to β-actin. The hepcidin/β-actin ratios are shown, each symbol representing 1 mouse. Statistical analysis was performed by 1-way ANOVA; **P < .001 for comparison with control mice. n.s. indicates not significant.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/113/15/10.1182_blood-2008-08-173641/7/zh80180934400002.jpeg?Expires=1724976804&Signature=DbNC5XF2yrXoC6m9ZKtApjKCj-b3YvFS2BlqOVFKo~a16g1lQ8nzmnzW-oHNtBY1BcP1vf1cbODLDZOPrliXWstOPYsLFEV~evtWCQkQdFhGFdjmaEyyH8UluO-R7uvrXYlT7e15KQke94JKvt9PGf0kTIH70hrRSeiYHQGEy7t4R6CWekBirDhWxxIqRm-Dwr2cQIP8hjaYhpdZDpiWe8h1wC1nKXT4YDpeqpVSzhzETzP2kwn-q0pk640w5JEcd8uF2LO6DlKkSOK265TN-Io09PMpC5eWR9YVyrNGVYxxgIp3ndbLheqTt5TXDyAejWAE4l-UhAJA-rc6dYD61g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Erythropoietin but not hypoxia inhibits hepcidin induction through the inflammatory pathway. (A) Hepcidin mRNA levels in the liver of mice treated with saline (control [CTL]), EPO, LPS, and mice with combined treatments (EPO + LPS). (B) Hepcidin mRNA levels in the liver of mice treated with saline (CTL), mice subjected to 10% oxygen (hypoxia [Hpx]), LPS, and mice with combined treatments (Hpx + LPS). Hepatic hepcidin expression was quantified by real-time RT-PCR and normalized to β-actin. The hepcidin/β-actin ratios are shown, each symbol representing 1 mouse. Statistical analysis was performed by 1-way ANOVA; **P < .001 for comparison with control mice. n.s. indicates not significant.
