Figure 5
![Figure 5. CD38 signaling requires Lyn, Fyn, PI3K, and Erk to induce proliferation of T2 B lymphocytes. (A) T2 B cells from Lyn−/−, Fyn−/−, or wild-type mice were stimulated 48 hours as indicated. (B) T2 B cells from wild-type mice were preincubated 30 minutes with DMSO, LY294002 (LY), or PD98059 (PD). Cells with the drug were stimulated as indicated above. Each well was pulsed with 1 μCi [3H] thymidine 8 hours before being harvested. Results are expressed as mean plus or minus SD from 3 independent experiments (P < .05 or P < .01 as indicated, Student t test).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/111/7/10.1182_blood-2007-08-107714/5/zh80070817550005.jpeg?Expires=1724276757&Signature=tgCWzp4dB8TwWcDOYKtzdFF6lU4yfmNJis659i-tMmVu6Ydwu0tREDYkOjH2pg~tc3s8BNGDHpHdaFwAeFAIidG9E~YLdIVcDcuj5KK5SAa8d~D8FriKkax26BznMLJFtHRLe834N~vT8R6riBnuDqJ8kcTokr9Ypx2v9lJB1qeMo9KqJcxkv3P8LA~tUoVntESzmosZlfJ~M62mg77pO2hxOIWB7Wb0BFN-roju4ir9QzoZ7kzklsua2LfR5mq~4YvkKupFeTa3n2f29N9NFiQoHvJJSCKt2s62tnfbHVLewinzd4uvbONVGBBI883nVW28Bu5SXB~5-OG5ddgK3w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CD38 signaling requires Lyn, Fyn, PI3K, and Erk to induce proliferation of T2 B lymphocytes. (A) T2 B cells from Lyn−/−, Fyn−/−, or wild-type mice were stimulated 48 hours as indicated. (B) T2 B cells from wild-type mice were preincubated 30 minutes with DMSO, LY294002 (LY), or PD98059 (PD). Cells with the drug were stimulated as indicated above. Each well was pulsed with 1 μCi [3H] thymidine 8 hours before being harvested. Results are expressed as mean plus or minus SD from 3 independent experiments (P < .05 or P < .01 as indicated, Student t test).
