Mouse DC populations, location, and turnover in steady state. DCs are distributed throughout the body. The major DC subpopulations at hematopoietic sites, environmental contact sites, filtering sites, and immune priming sites are depicted. Frequencies are given as percentage of total nucleated hematopoietic cells. Time to approximately 50% renewal in steady state is given in days (d). *Skin-draining LN; **epidermis; +present, but exact numbers not known; ↑, present in inflammation. Professional illustration by Debra T. Dartez.