Peptide 12 sustains neoangiogenesis in vivo. (A) The effect of 100 μg/pellet of peptide 12 or Y220A peptide was compared with that of 400 ng/pellet VEGF-A. *Pellet implants. (B) Quantification of the data (means ± SEM) shown in panel A reported as angiogenic score during time (days). Numbers are the means of 6 implants for each experimental point. One-way analysis of variance (P < .001). *P < .05 peptide 12 versus Y220A peptide (Student-Newman-Keuls multiple comparison test).