Treatment of WM SCID-hu mice with SGN-70. Effect of SGN-70 on disease progression as assessed by serial changes in serum IgM (A) and sCD27 (B) levels in SCID-hu mice engrafted with BCWM.1 WM LPCs. Group 1 denotes untreated mice (n = 5), and group 2 denotes mice treated with SGN-70 (n = 12).