Figure 3
The disease progression in the MMTV-Cre;Mib1f/f mice. (A) Biweekly monitoring of the peripheral blood cells from MMTV-Cre;Mib1+/f (dotted line, representative data) and MMTV-Cre;Mib1f/f (solid line, 9 individuals) mice by flow cytometry. (B,C) The representative CD11b/Gr-1 (B) and B220/CD11b (C) expression profiles of the blood cells of MMTV-Cre;Mib1+/f (WT) and MMTV-Cre;Mib1f/f (MT) mice are shown. (B′) Flow cytometric analysis of the CD11b+Gr-1lo/− gated blood cells from WT (i) and MT (ii) at 20 and 15 weeks of age, respectively. Note that the CD11b+Gr-1lo/− cells consisted of a significant proportion of CCR-3+ and SSChi cells in the blood cells of MT.

The disease progression in the MMTV-Cre;Mib1f/f mice. (A) Biweekly monitoring of the peripheral blood cells from MMTV-Cre;Mib1+/f (dotted line, representative data) and MMTV-Cre;Mib1f/f (solid line, 9 individuals) mice by flow cytometry. (B,C) The representative CD11b/Gr-1 (B) and B220/CD11b (C) expression profiles of the blood cells of MMTV-Cre;Mib1+/f (WT) and MMTV-Cre;Mib1f/f (MT) mice are shown. (B′) Flow cytometric analysis of the CD11b+Gr-1lo/− gated blood cells from WT (i) and MT (ii) at 20 and 15 weeks of age, respectively. Note that the CD11b+Gr-1lo/− cells consisted of a significant proportion of CCR-3+ and SSChi cells in the blood cells of MT.

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