The SRCs from patients with PV and JAK2V617F-positive myelofibrosis have a different differentiation program. (A) The percentages of myeloid (▭) and B-lymphoid () cells within the human graft of PV (n = 8), PMF (n = 4), and PPV-MF3 reconstituted mice. (B) Flow cytometric analysis of the BM of 3 representative mice, receiving a transplant of PV, PMF, or PPV-MF CD34⁺ cells. (Top panel) SSC versus CD45 analysis showing human cells (CD45⁺). (Bottom panel) CD45⁺ cells analyzed for CD33 and CD19 expression, showing human myeloid (CD45⁺CD33⁺) and B-lymphoid (CD45⁺CD19⁺) cells.