Microarray time course analysis of LECs treated with VEGF-A or VEGF-C reveals 4 major temporally regulated gene clusters. Transcription profiling and STEM analysis of LECs stimulated with VEGF-A or VEGF-C, respectively, for 1, 4, 8, or 24 hours revealed 97 and 100 genes specifically up-regulated at 1 hour (early response genes), 51 and 43 genes up-regulated transiently (transiently induced), 87 and 43 genes up-regulated progressively over time (progressively induced) and 59 and 45 genes down-regulated over time (down-regulated).