PFS and probability of CCyR for patients who met criteria of failure at 3, 6, 12, or 18 months and for patients who met criteria of failure and suboptimal response at 3, 6, or 12 months. (A) The PFS and probability of CCyR for patients who met the criteria of failure at 3, 6, 12, or 18 months (dashed line) compared with those patients who never met criteria for failure (continuous line); the 5-year PFS was 63.8% versus 90.8% (P < .001), and the 5-year probability of CCyR was 46.3% versus 100% (P < .001). (B) The PFS and probability of CCyR for patients who met either criteria of failure or suboptimal response at 3, 6, or 12 months (dashed line) compared with those patients who did not meet criteria for failure or suboptimal response at 3, 6, and 12 months; the 5-year PFS was 70.4% versus 95.9% (P < .001), and the probability of CCyR was 51.4% versus 100% (P < .001). Vertical lines represent censored patients (but the corresponding lines are not shown in the CCyR curves). In the 18- and 12-month values, 100% of the patients in the responding groups were in CCyR (by definition).