Differential STAT3 signature expression in subsets of ABC DLBCLs. (A) The expression levels of STAT3 and STAT3 target genes in the subgroup predictor in 92 ABC DLBCL tumor samples. The probabilities that the ABC DLBCL samples belong to the STAT3-high and STAT3-low subgroups based on a Bayesian predictor (see “Methods”) are graphed at the top, and the cases are arranged accordingly. The cases that belong to either the STAT3-high or STAT3-low ABC DLBCL subgroups with more than 90% likelihood are indicated. (B) Mean STAT3 mRNA, IL-6 mRNA, and IL-10 mRNA levels among STAT3-high ABC DLBCL, STAT3-low ABC DLBCL, and GCB DLBCL. (C) Expression of STAT3 target genes and ABC DLBCL signature genes in STAT3-high ABC DLBCL, STAT3-low ABC DLBCL, and GCB DLBCL. (D) Average expression of STAT3 target genes and ABC DLBCL signature genes in STAT3-high ABC DLBCL, STAT3-low ABC DLBCL, and GCB DLBCL.