Prognostic value of the gene-expression signature in patients with high-risk molecular features. To visualize the prognostic value of the gene-expression predictor in patients who either carry a FLT3 ITD or are FLT3 ITD⁻/NPM1⁻, score values were dichotomized based on the cutoff value defined in the training cohort. (A) Kaplan-Meier plots of OS of molecular high-risk patients in the test cohort. (B) OS of molecular high-risk patients in the validation cohort.