Collagen deposition in lungs from unsensitized and sensitized WT, HbA, and SCD mice. (A) This figure shows images of McLetchie trichrome staining of lungs from UnSen, LoSen, and HiSen WT, HbA, and SCD mice. First row: Images of lung sections from UnSen (Un), LoSen (Lo), and HiSen (Hi) WT mice. Second row: Images of lung sections from UnSen (Un), LoSen (Lo), and HiSen (Hi) HbA mice. Third row: Images of lung sections from UnSen (Un), LoSen (Lo), and HiSen (Hi) SCD mice. Basement membrane thickening in the (B) peribronchial and (C) perivascular regions of the lungs from UnSen, LoSen, and HiSen WT, HbA, and SCD mice. Statistical analysis: * indicates significantly different from UnSen group within same strain; §, significantly different from LoSen (Lo) group within same strain; †, significantly different from wild-type (WT) group with same treatment; and ‡, significantly different from the HbA groups with same treatment. (P < .05, adjusted for the number of comparisons.)