Combined effect of DHFR, TS, and CCND1 genes on EFS in patients with ALL. The EFS curves for HSJ patients having 0, 1, 2, or 3 event-predisposing genotypes. Event-predisposing genotype for DHFR was haplotype *1; for TS, it was homozygosity for the 3R allele; and for CCND1, it was homozygosity for the A870 variant. The numbers of patients in each curve, numbers of individuals with an event (in parentheses), as well as the P value, are indicated on each plot.