Figure 5
Figure 5. IL-2 complexes preferentially induce the accumulation of KLRG1hiCD127loCD8+ T cells. (A) B6 mice were treated with or without IL-2 complexes as outlined in Figure 1A. The percentage of donor OT-I cells present among PBLs is shown. (B) B6 mice were treated with or without IL-2 complexes as outlined in Figure 1D. The percentage of tetramer+ CD8+ T cells present among PBLs is shown. (C) CD127 and KLRG1 coexpression on donor OT-I T cells in the spleen on day 17 after infection as described in panel A. (D) CD127 and KLRG1 coexpression on tetramer+ CD8+ T cells in the spleen on day 15 after infection as described in panel B. (E) Absolute numbers of donor OT-I CD8+ T-cell subsets on day 17 after infection as described in panel A. (F) BrdU incorporation on donor OT-I T cells from mice with or without treatment with IL-2 complexes as outlined in Figure 4A.

IL-2 complexes preferentially induce the accumulation of KLRG1hiCD127loCD8+ T cells. (A) B6 mice were treated with or without IL-2 complexes as outlined in Figure 1A. The percentage of donor OT-I cells present among PBLs is shown. (B) B6 mice were treated with or without IL-2 complexes as outlined in Figure 1D. The percentage of tetramer+ CD8+ T cells present among PBLs is shown. (C) CD127 and KLRG1 coexpression on donor OT-I T cells in the spleen on day 17 after infection as described in panel A. (D) CD127 and KLRG1 coexpression on tetramer+ CD8+ T cells in the spleen on day 15 after infection as described in panel B. (E) Absolute numbers of donor OT-I CD8+ T-cell subsets on day 17 after infection as described in panel A. (F) BrdU incorporation on donor OT-I T cells from mice with or without treatment with IL-2 complexes as outlined in Figure 4A.

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