Networks of TP53-regulated genes in MM cell lines and patients. Ingenuity Pathways Analysis software (Ingenuity Systems) was used to analyze the identified genes (n = 85). Three networks were identified. The network representing proteins involved in the biologic functions of cancer and the cell cycle is shown. The genes written in bold letters with a shaded node were identified by microarray analysis, and the other genes were those related to the regulated genes based on the network analysis. The intensity of a node color indicates the degree of up-regulation (red). The meanings of node shapes are indicated in the figure.