VWF is not required for LPS-induced thrombocytopenia.Adamts13^+/− mice that were either deficient for VWF (Vwf^−/−, dashed line with triangles) or expressing VWF (Vwf^+/−, solid line with circles) were injected intraperitoneally with LPS (either 12 or 20 μg/g body weight) and followed for 4 days. Blood from the retro-orbital plexus was obtained daily for automated platelet count analysis. For each group of mice, the daily platelet count data were averaged and expressed as the percentage change from baseline values obtained before injection of LPS. The number of mice injected was 12 for each group (8 mice at 12 μg/g, and 4 mice at 20 μg/g). The error bars represent the standard error of the mean.