Cell profile and associated cytokine and chemokine release in resolving inflammation. We established 2 models of inflammation—one where a low dose of zymosan (0.1 mg, □) was injected intraperitoneally causing a transient acute inflammatory response that resolved, as well as another model where 10 mg zymosan was injected (■) triggering a more aggressive inflammation. (A) Gr1(LY6G)-positive granulocytes and (B) F4/80-labeled macrophages were enumerated in each model over time by hemocytometer and FACS analysis. (C) Levels of typical proinflammatory cytokines were quantified in the cell-free inflammatory exudates at several time points during and after resolution in both models as well as (D) in plasma 2 weeks after resolution to determine whether inflammation resolved or became systemic. n = 6 to 8 mice per group with data expressed as mean plus or minus SEM.