Telomere lengths in patients with DC with TINF2 mutations are the shortest compared with other DC subtypes. (A) Telomere lengths in healthy controls (○, n = 112), patients (♦, n = 16) and parents (, n = 15). (B) Telomere length compassion between DC patients with TINF2 mutations (♦, n = 16), DKC1 mutations (, n = 67) and healthy controls (○, n = 112). The line of best fit for the healthy controls is shown in panels A and B. (C) Comparison of age-adjusted delta Tel in healthy controls and patients with DKC1 and TINF2 mutations. The box represents the interquartile range which contains the 50% of values. The whiskers are lines that extend from the box to the highest and lowest values, excluding outliers and extreme outliers (○ and , respectively). A line across the box indicates the median.