The TNF gene locus. The haplotype-tagging SNPs span a 25-kb region across the IκBL, LTA and TNF loci (rs numbers are from NCBI dbSNP build 129 released June 18, 2008, www.ncbi.nlm.nih.gov/projects/SNP/). The SNPs are designated according to the nucleotide position relative to the transcriptional starting site of TNF. Filled boxes represent exons.