Myeloproliferative disease develops in mice with FLT3^wt/ITD mutation. (A) Kaplan-Meier plot of survival of FLT3^wt/ITD and wild-type control mice (n = 12). (B) FLT3^wt/ITD mice manifested splenomegaly. Peripheral WBC count (C) and WBC differential (D) in 12-month-old FLT3^wt/ITD and wild-type mice (n = 10) are shown. wt indicates wild-type. *P < .05. Data in panel C are expressed as means (bars) plus or minus SEM (error bars).