Heatmap display of cytokine protein profiling and signaling protein analysis highlights the difference in patterns underlying distinct biologic processes embodied in FL and FH. Results are displayed for FL (N = 36) and FH (N = 22) samples. Heatmap depicts the “fold change” of the designated protein concentration of each specimen relative to the median value of the designated cytokine or signaling protein across all specimens. The color red indicates relatively high protein concentration and the color green indicates relatively low protein concentration.