DCs physically interact with myeloma cells. Bone marrow biopsy from patient 88 with recurring MM was stained for CD138 for myeloma cells (brown-staining cells; left panel; magnification, 40×/0.55 NA N PLAN objective) or fascin for DCs (brown-staining cells; right panel; magnification, 100×/1.4 NA oil objective). Photomicrograph of fascin⁺ cells was taken from a region in the center of the field shown in the left panel. Arrows point to interdigitating DC dendrites.