Thrombin generation in FV-deficient plasma. (A) TF-titration of thrombin generation in FV-deficient plasma. Thrombin generation was determined in plasma from patient GK 506 at 0, 34, 68, 136, 272, and 544 pM TF. Inset shows peak height of thrombin generation as a function of TF concentration. (B) Peak height of thrombin generation evoked by 544 pM TF in normal pooled plasma (NPP) and in plasma from patients with severe FV deficiency.