Combination cytotoxicity of ABT-737 and L-ASP, vincristine, or dexamethasone. Dose-response curves of ALL cell lines to ABT-737 (●), L-ASP (△), vincristine (VCR; ○), dexamethasone (DEX; □), and the combinations: ABT-737 + L-ASP (▲), ABT-737 + VCR (), and ABT-737 + DEX (gray squares). The concentrations applied for the cell lines were 0.5 to 5 μM for ABT-737; 0.1 to 1 IU/mL for L-ASP; 5 to 50 ng/mL for VCR; and 50 to 500 nM for DEX. Each condition had 12 replicates, and error bars represent standard deviation. The CI values are shown in Table 1.