Figure 1
The expression of 4-1BB and CD27 by CD8 T cells during the response to anti-CD40. Mice were inoculated with 5 × 107 BCL1 cells intravenously and treated with anti-CD40 mAb (1 mg) 4 days later. On the days indicated, the expression of 4-1BB and CD27 on splenic CD8 T cells was monitored by flow cytometry. (A) The dot plots show the expression of 4-1BB (top) and CD27 (bottom) on CD8 T cells in mice 3 days after anti-CD40 treatment compared with untreated controls. (B-C) The histograms show the changes in 4-1BB and CD27 expression on CD8 cells on days 3 to 6 following anti-CD40 and in untreated controls (left); gray lines show the expression level in naive mice. Results represent 1 of 3 similar experiments.
